منابع مشابه
Security Patch Management: Share the Burden or Share the Damage?
P management is a crucial component of information security management. An important problem within this context from a vendor’s perspective is to determine how to release patches to fix vulnerabilities in its software. From a firm’s perspective, the issue is how to update vulnerable systems with available patches. In this paper, we develop a game-theoretic model to study the strategic interact...
متن کاملi-SNAREs
A new functional class of SNAREs, designated inhibitory SNAREs (i-SNAREs), is described here. An i-SNARE inhibits fusion by substituting for or binding to a subunit of a fusogenic SNAREpin to form a nonfusogenic complex. Golgi-localized SNAREs were tested for i-SNARE activity by adding them as a fifth SNARE together with four other SNAREs that mediate Golgi fusion reactions. A striking pattern ...
متن کاملSNAREs drum up calcium
SNAREs drum up calcium n page 195, Merz and Wickner show that when two intracellular vesicles fuse, the interaction of their SNARE proteins triggers a short-lived calcium release. The work provides the first clear connection between calcium release and the fusion cycle, and supports a model in which the pairing of SNAREs in trans coordinates the downstream signals that lead to vesicle fusion. P...
متن کاملp115 SNAREs a vesicle
p115 SNAREs a vesicle protein known to tether vesicles during intra-Golgi trafficking also ensures their correct docking, according to new results from Shorter et al. (page 45). This provides the first link between the long-range process of tethering and the short-range process of docking. Vesicle transfer consists of four successive reactions: vesicle formation, tethering, docking, and fusion....
متن کاملSNAREs and traffic.
SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) are now generally accepted to be the major players in the final stage of the docking and the subsequent fusion of diverse vesicle-mediated transport events. The SNARE-mediated process is conserved evolutionally from yeast to human, as well as mechanistically and structurally across different transport events in euka...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2015
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2103iti2